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desvenlafaxine will improve the amount or impact of codeine by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor. Desvenlafaxine inhibits CYP2D6; with increased desvenlafaxine doses (ie, four hundred mg) reduce the CYP2D6 substrate dose by as many as 50%; no dosage adjustment necessary with desvenlafaxine doses seven consecutive days